Noobie GM here, trying to get into the "settings mindset."
I'd say to understand EP's idiosincracies let's start with what t-hummies fear.
Before the Fall, humanity's main fear was dying (or not knowing what's beyond, etc.), right?
With that technically "gone" what would you say the new fears are now?
I'll start w/some of my ideas (that may be mistaken, after all I'm trying to wrap my head round this peculiar setting):
:Isolation (everything's pervasive with the Mesh)?
:Loss of identity (People not knowing you - you got forked/cloned/copied)?
Anything else (thoughts, suggestions, corrections, ideas) from the community would be of great-grand-grandest help.