The Exhumans are an NPC faction in Eclipse Phase that take self-modification to the extreme. They seek to become posthuman, or more accurately, something altogether different and better than human. Some of them tinker with extreme genetic mods while others pursue cognitive alterations that radically alter their mindset. Though individual Exhumans pursue different ideals, they are generally hostile to transhumanity, considering them backwards and primitive.
This particular illustration is from Davi Blight.